#88 Meet The Neuroscientist Who Created The Best Universal Theory Of Brain Function

The Giants Shoulder • January 25, 2026 • Solo Episode

View Original Episode

Guests

No guests identified for this episode.

Description

Karl Friston is one of the most influential neuroscientists alive and the creator of the Free Energy Principle, a unifying theory that aims to explain how brains perceive, act, learn, and remain alive in an uncertain world.SPONSORS:Get 1 Week Free of ConsensusAi: https://get.consensus.app/giantsshoulder1Mind Labs Pro Scientifically Rigorous Supplements: https://www.mindlabpro.com/?a_aid=67fd1cb8d9ad3&a_bid=6d45f5c3The brain is not a passive receiver of information. It is an active prediction machine, constantly generating expectations about the world and the body, updating those beliefs when they fail, and acting to make its predictions come true. Under this framework, perception is inference, action is prediction fulfilment, emotion is bodily forecasting, and the self is a model the brain uses to explain its own persistence.Expect to learn what the Free Energy Principle actually is, why living systems must minimise surprise, how predictive coding and active inference work, why perception is a controlled hallucination, how attention and precision shape experience, what interoceptive inference reveals about emotion and the self, how psychedelics relax beliefs, where consciousness might fit in a predictive hierarchy, and why this theory may be one of the deepest explanations of mind we currently have.Timestamps: 00:00 Introduction to the Free Energy Principle02:54 Deflationary Nature of the Free Energy Principle05:48 Explaining the Free Energy Principle: High Road vs. Low Road09:02 Predictive Processing and Perception11:49 Active Inference and Its Implications15:07 Interoception and Emotional Inference18:02 Generative Models and Selfhood20:54 The Role of Emotions in Predictive Coding23:55 Transformative Experiences and Learning26:44 Conclusion: The Practical Applications of the Free Energy Principle48:58 Understanding the Role of Psychedelics in Therapy52:48 Mechanisms of False Inference and Precision in the Brain57:24 Relaxing Priors: The Impact of Psychedelics on Sense-Making01:01:03 Generative Models: Individual Differences and Shared Structures01:06:49 Cognitively Impenetrable Illusions and Prior Beliefs01:15:15 Sensory Attenuation and the Role of Attention01:19:03 The Free Energy Principle: Implications for Psychiatry01:25:48 The Future of Neuroscience Education and Research...❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Audio