Columbia CS Professor: Why LLMs Can’t Discover New Science

The a16z Podcast • October 13, 2025

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From GPT-1 to GPT-5, LLMs have made tremendous progress in modeling human language. But can they go beyond that to make new discoveries and move the needle on scientific progress? We sat down with distinguished Columbia CS professor Vishal Misra to discuss this, plus why chain-of-thought reasoning works so well, what real AGI would look like, and what actually causes hallucinations.

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