Profluent raises $106M from Jeff Bezos

Air Street Press • November 20, 2025 • Solo Episode

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Profluent builds frontier AI systems to unlock programmable biology. Now, Profluent has raised $106M led by Bezos Expeditions and Altimeter, with continued support from Spark, Insight, and Air Street. The company is now the largest position in Air Street’s second fund. This new capital accelerates the company’s path toward scaling frontier protein models and, ultimately, delivering the first AI-designed therapeutic to a human patient.

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